The pre-dawn bus crash in Central Virginia that killed four and injured at least 50 others is prompting more inquiries into driver safety after the Virginia State Police blamed driver fatigue for the fatal accident. The bus, operated by Sky Express, was carrying 53 people from Greensboro, N.C., to New York City when it ran off the roadway and flipped onto its roof at about 5 a.m. this morning.

Sky Express, of Charlotte, N.C., has an F rating from the Better Business Bureau based on their failure to respond to two complaints against the business and on its failure to provide information to the Southern Piedmont/Charlottte bureau, according to its website.

The Virginia accident comes two months after 14 people were killed in an accident on a Bronx highway involving a bus returning to New York City from the Mohegan Sun casino in Uncasville, Conn. That accident was likely caused by driver fatigue. The operator of the bus in the May 12 incident, World Wide Tours of Greater New York, had been flagged for extra scrutiny by the Federal Motor Carrier Safety Administration because of violations of driver fatigue rules, and the company was involved in two previous accidents in the last two years that injured passengers.

The Federal Motor Carrier Safety Administration did nearly 2,800 spot safety checks of passenger buses across the country from March 28 through April 6, resulting in about 10% of the vehicles or drivers being removed from the road, according to U.S. Transportation Secretary Ray LaHood.