Ryan Fitzpatrick
in 2012, Ryan Fitzpatrick three 24 touchdowns and 16 interceptions as the starter for the Buffalo Bills. Reuters

The Indianapolis Colts and Tennessee Titans suffered the two worst losses of last week. Both teams will look for redemption in a game against each other to begin the Week 11 schedule.

The first-place Colts had what was thought to be an easy win, facing the St. Louis Rams at home. Not only did the Rams have no problem covering the 9.5-point spread, but they won handily, defeating Indianapolis, 38-8. Career-backup Kellen Clemens outplayed Andrew Luck, who threw three interceptions in the loss.

“Certainly we're not going to bury our head in the sand on this past ball game," head coach Chuck Pagano said. "We'll address the issues like we always address them. We know there are things that need to be fixed and we'll go to work on fixing those things."

Tennessee suffered the biggest upset of the season. They entered their matchup with the Jacksonville Jaguars as two-touchdown favorites and gave the NFL’s worst team their first victory of 2013. The Titans outgained their opponent by 148 total yards, but were hurt by turnovers in their own territory. Prior to the contest, the Jaguars had lost every game by double-digits.

The final score, though, might not have been the worst thing that happened to the Jaguars in Week 10. Starting quarterback Jake Locker was forced to leave the contest with a foot injury. Ryan Fitzpatrick finished the rest of the game, and now will have to finish the rest of the season. Locker is done for the year because of a Lisfranc injury that could force him to undergo surgery.

"Ryan knows he's got to play, we need him to step up," tight end Delanie Walker said. "Ryan has no choice but to play good. I feel like he did a great job against the Jaguars. It's his opportunity to be the man now."

Indianapolis won’t be facing a traditional backup like they did last week. Fitzpatrick started the majority of his team’s games from 2008-2012. He’s played in four games this year because of injuries to Locker, registering a 76.0 passer rating, while throwing four touchdowns and four interceptions.

A win for Tennessee last week would have put them just one game behind the Colts atop the AFC South. At 4-5, though, they won’t be able to get a share of first place with a win. Indianapolis is still a heavy favorite to win the division. Other than the Titans, the Jaguars and Houston Texans have just three combined wins.

As the two teams square off on "Thursday Night Football," the Colts are favored on the road. The betting line has them giving the Titans three points, who have overachieved away from their home fans. The Titans are 2-2 straight up on the road, but they are 4-0 against the point spread.

At times this year, the Colts have been viewed as one of the best teams in the league. However, they continue to struggle against inferior competition. They are 2-4 against the spread a favorites, including three outright losses.

Prediction: Tennessee 24, Indianapolis 23