The time has come to dive headfirst into yet another exciting season of ABC’s “Grey’s Anatomy.” A number of spoilers have been released about Season 13, revealing to viewers that this installment is sure to be a doosie.

When the show left off one of the newest additions to the Grey Sloan Memorial Hospital team found himself in need of treatment due to injuries he suffered at the hands of another, more senior, doctor. It seems this fact will serve as a tipping point in Season 13, with the Sept. 22 premiere kicking off with DeLuca’s (Giacomo Gianniotti) hospitalization. While doctor’s rush to help, others are trying to hold it together. Photos from the set, as well as a brief synopsis released by ABC, suggest that Meredith (Ellen Pompeo) will spend much of the premiere battling with a dark secret that threatens to ruin her relationship with half-sister Maggie (Kelly McCreary) and Alex (Justin Chambers), who is dealing with demons of his own.

That’s not all ABC and “Grey’s Anatomy” creator Shonda Rhimes have in store. There will be plenty of drama to go around, as always. Here is everything we know so far about Season 13 of “Grey’s Anatomy”:

Alex may have to face the consequences of his actions:

In the Season 12 finale, a misunderstanding between Alex and DeLuca left the New Zealand native in serious condition. Bloody and battered, he will be admitted to the hospital in the Season 13 premiere. While he fights for his life, Alex will have to cross his fingers and pray no one finds out it was him who hurt DeLuca.

Meredith’s got a secret:

In Season 13, Meredith will find herself caught in the middle once more. The veteran surgeon will be tasked with keeping a secret that could cost her the relationships she’s built with both Maggie and Alex. Photos from the set show a tense confrontation with her half-sister and another with Richard (James Pickens Jr.).

Jackson (Jesse Williams) and April (Sarah Drew) may reunite:

Photos show new parents Jackson and April — who are divorced — enjoying their first moments with their child. The two appear happy as they look down at the newborn, but it’s the way they’re looking at one another that has “Grey’s Anatomy” fans speculating. Jackson and April’s relationship has been complicated from the start and it seems that’s not going to change in Season 13.

Issues of domestic violence will play a central role:

Jo (Camilla Luddington) revealed in the Season 12 finale that she is married to a man that was abusive to her. She cannot confront him, as she fears he will hurt her again, meaning her and Alex can’t get married. It remains unclear whether she will share this secret with her beau, but it seems likely. Will he confront her abuser? Viewers will just have to tune in to find out.

“I don’t think that I ever think about doing things, like, Oh, we’re doing a domestic violence story as an issue,” Rhimes told Entertainment Weekly. “It felt like it was time to tell Jo’s story, and it felt like it was time to tell Jo’s story especially in the context of Alex, who he is and how he grew up. Alex is so defined by who he used to be and who is trying to become, and so is Jo.”

Arizona (Jessica Capshaw) will fall in love again:

Following her split from wife Callie (Sarah Ramirez) — who is no longer on “Grey’s Anatomy” — Arizona had all but given up on love. In Season 13, she will find herself in yet another romantic situation, though it has yet to be revealed which lucky lady will steal her affections. Although Arizona’s story will be an important one in the upcoming season, she will be absent from a couple of early episodes.

Meredith and Rigg’s (Martin Henderson) romance will cause drama with Maggie:

Meredith has found love again following a split from husband Derek (Patrick Dempsey), but not everyone is happy for her. What began as a secret fling will start spreading around the hospital and when it gets to Maggie, she will be open about how uncomfortable it makes her.

“One of the things that we know about Maggie is that she is really a stickler for honesty and the truth,” McCreary told TV Guide in August. “In her first season, she really holds it against Richard that he didn’t tell her [he was her father] right away, that he withheld the truth for any length of time. To me, that’s an indication of how we can expect Maggie to feel about any lack of honesty, any lack of full transparency and disclosure in a relationship — especially with somebody that she trusts and, more than trusts, really relies upon as much as Meredith.”

Owen (Kevin McKidd) and Amelia (Caterina Scorsone) likely won’t have a baby:

Scorsone announced, during the Television Critics Association’s summer press tour in August, that she was having a child of her own. This news excited fans, but left them wondering how creator Shonda Rhimes planned to tackle her growing bump on the show. Scorsone told Entertainment Weekly that fans probably won’t see an Owelia baby in Season 13, as writers “don’t want to burn through all that story.” Instead, they’ll do their best to hide her pregnancy for as long as possible with “super camera work and super wardrobe time.”

“Grey’s Anatomy” premieres Season 13 on Thursday at 8 p.m. EDT on ABC.